RAF Typhoon fighter aircraft have joined forces with French warplanes in a coordinated attack targeting an subterranean weapons facility in Syria employed by the IS group, according to the British defence ministry.
The site, pinpointed through surveillance, was believed to be containing munitions and bombs, the statement said, and was located in hills just to the north of the historic site of Palmyra in the heart of Syria.
"Our aircraft used laser-guided Paveway IV weapons to hit a series of approach shafts providing entry to the facility... initial indications are that the strike was effective," the MoD said.
There was no indication of any civilian casualties in the attack late on Saturday and every plane involved returned to base without incident, the MoD added.
The British jets were supported by a Voyager refuelling tanker.
Daesh - alternatively referred to as the so-called Islamic State - imposed jihadist rule over significant areas in Iraq and Syria until 2019.
"This strike shows British leadership, and resolve to operate in unison with our partners, to eradicate any resurgence of Daesh and their dangerous and violent ideologies in the region," the British Defence Secretary the Defence Secretary remarked.
British military aircraft have carried out patrols over Syrian airspace to "forestall any attempted comeback" of the group after its defeat at the Baghuz confrontation in the year 2019, the authorities noted.
"I must thank all the members of British forces who took part in this operation for their professionalism and their bravery," Healey said. "Including them were numerous UK service members on duty over the holidays. This operation, to remove terrorist threats who pose a risk to our safety, highlights how UK forces are ready to step up, all year round, ensuring Britain's security domestically and strong abroad."
During December, the American forces executed what it described as a "large-scale strike" on Daesh sites in the country, following an attack claimed the lives of two American soldiers and a civilian linguist in the Palmyra area.
The United Nations estimates Islamic State still has an estimated 5,000 to 7,000 militants in both countries.